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Protection. Education. Connection. There's an app for that at ascpskincare.com/app 51 INGREDIENT DECK PROFESSIONAL INTEGRATION RECOMMENDATIONS Some clients might benefi t more from PDRN treatments. Ideal clients might be postprocedure clients requiring enhanced healing support, barrier- compromised skin conditions, clients seeking gentle regenerative treatments, and those with contraindications to more aggressive therapies. When integrating PDRN into your client's treatments, begin with lower concentrations to assess tolerance. Combine with appropriate delivery methods (microneedling, iontophoresis), monitor the healing progression, and adjust frequency accordingly. Finally, document outcomes for treatment refi nement. Before getting started, consider the following contraindications and precautions: • Active inflammatory conditions (assess individually) • Concurrent use with certain actives (evaluate compatibility) • Known seafood allergies (for salmon-derived products) • Pregnancy/lactation (limited safety data) PROFESSIONAL TAKEAWAYS PDRN is a true milestone in regenerative skin care. Understanding its journey from 1980s medical research to today's botanical innovations gives professionals valuable background for educating their clients, selecting the right brands and formulations, and integrating this ingredient into treatments with confi dence and precision. The PDRN market continues evolving toward sustainable, inclusive formulations while maintaining clinical effi cacy. When introducing PDRN into your practice, salmon-derived formulations remain the gold standard, with the most clinical evidence supporting their results. At the same time, ginseng- derived alternatives are an excellent option when sustainability, inclusivity, or client sensitivities are top priorities. For professionals looking to stand out with treatments that are both innovative and rooted in solid science, PDRN delivers a compelling edge, off ering proven effi cacy, gentle application methods, and alignment with the growing demand for clean, conscious skin care. Notes 1. Francesco Squadrito et al., "Pharmacological Activity and Clinical Use of PDRN," Frontiers in Pharmacology 8 (April 2017): 224, doi.org/10.3389/fphar.2017.00224. 2. Faiza Hussain, In-Cosmetics. "The Rise of PDRN Skincare," March 21, 2025, connect.in-cosmetics.com/ingredients/pdrn. 3. Squadrito et al., "Pharmacological Activity and Clinical Use of PDRN." Resources Kim, T.-H. et al. "Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering." Marine Drugs 19, no. 6 (May 2021): 296. doi.org/10.3390/md19060296. Lee, K.-S. et al. "Analysis of Skin Regeneration and Barrier- Improvement E cacy of Polydeoxyribonucleotide Isolated from Panax Ginseng (C.A. Mey.) Adventitious Root." Molecules 28, no. 21 (October 2023): 7240. doi.org/10.3390/molecules28217240. Naik V. et al. "The Impact of Polydeoxyribonucleotide on Wound Healing: A Systematic Review." International Surgery Journal 12, no. 4 (April 2025). doi.org/10.18203/2349-2902.isj20250816. GETTY IMAGES