ASCP Skin Deep

AUTUMN 2025

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Protection. Education. Connection. There's an app for that at ascpskincare.com/app 47 the adenosine A2A receptor, which is a pathway that encourages growth-factor release, supports new capillary formation via vascular endothelial growth factor (VEGF), and delivers a soothing, anti-infl ammatory eff ect. Clinical effi cacy data demonstrate: • Enhanced wound healing—Studies show 67 percent complete healing rates with PDRN and hyaluronic acid versus 22 percent with hyaluronic acid alone in patients with venous ulcers. 3 • Collagen stimulation—PDRN promotes fibroblast proliferation and collagen accumulation through modulation of the extracellular signal- regulated kinases (ERK) pathway, the pathway that controls various cellular processes. • Anti-inflammatory effects—PDRN aids in a significant reduction in TNF-α levels (a type of protein that, in excess, can signal inflammation and infection) and enhanced VEGF expression. • Barrier restoration—PDRN accelerates epithelialization and improves markers of skin hydration. These outcomes translate directly to posttreatment benefi ts, making PDRN particularly valuable for services like microneedling recovery, postlaser healing, chemical peel aftercare, and general barrier repair treatments. CONSIDERATIONS: ALLERGIES AND ALTERNATIVES When recommending PDRN treatments, it's crucial to check for seafood allergies, since traditional salmon- derived formulations can trigger reactions in sensitive clients. Additionally, vegan clients may prefer plant- based alternatives for ethical reasons. This awareness has driven signifi cant innovation in botanical PDRN alternatives, off ering estheticians more inclusive treatment options. The Development of Botanical PDRN Thanks to biotech advances, PDRN is no longer just a salmon story. Today, it can be sourced from plants like Korean ginseng (Panax ginseng), where microfl uidization—a high-pressure grinding technique—allows researchers to isolate plant- derived PDRN with comparable benefi ts. Even better, advances in biomimetic fermentation make it possible to create PDRN from nucleotide- rich botanicals like spirulina, off ering a vegan, cruelty-free option that delivers the same skin- repairing results as its traditional salmon-derived counterpart. So, what does botanical PDRN do? • Promotes keratinocyte and fibroblast proliferation through identical pathways • Activates adenosine A2A receptors with similar efficiency to salmon-derived variants INGREDIENT DECK Advances in biomimetic fermentation make it possible to create PDRN from nucleotide-rich botanicals like spirulina, offering a vegan, cruelty-free option that delivers the same skin-repairing results.

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