Issue link: https://www.ascpskindeepdigital.com/i/1531085
Protect your practice with the gold standard in liability coverage at ascpskincare.com 41 INGREDIENT DECK Flavonoids Though flavonoids are easily associated with a particular flavor of plants, fruits, vegetables, herbs, spices, and so on, they are also polyphenolic compounds that boast skin benefits. In cica, the benefits of these compounds provide a wide range of potential. Exploring just a few, the effects on the skin range from enhanced wound healing to improved skin hydration and support of protective mechanisms. Following are some flavonoids in cica: • Apigenin—helps ameliorate skin damage by activating anti-inflammatory and antioxidative responses • Catechin—powerful antioxidant potential that helps prevent photoaging • Naringenin—related to naringin and shown to improve skin hydration, elasticity, and reduce fine lines and wrinkles as well as protect against UV and pollution-induced skin aging • Naringin—promotes wound healing and collagen synthesis, improves skin hydration, and provides anti-inflammatory and antioxidant benefits • Quercetin—calms inflammatory skin conditions, exhibits antioxidant effects, protects against UV- induced skin damage FROM FOLKLORE TO FACT The combination of triterpenoids and flavonoids in this skin-friendly plant not only explains its long history of intuitive use but also proves relevant to modern skin care modalities and philosophies. This may explain its use in product formulations intended to support compromised skin. As we continue to explore and enjoy the vast world of skin care ingredients, cica (or however you want to refer to it) moves from folklore to fact as a formidable ally for maintaining healthy skin. Cica's rich history in traditional medicine, bolstered by modern scientific research, highlights its effectiveness in promoting skin regeneration, hydration, and protection. Resources Bylka, W. et al. "Centella asiatica in Cosmetology." Advances in Dermatology and Allergology 30, no. 1 (February 2013): 46–9. doi.org/10.5114/pdia.2013.33378. Ghiulai, R. et al. "Tetracyclic and Pentacyclic Triterpenes with High Therapeutic Efficiency in Wound Healing Approaches." Molecules 25, no. 23 (November 2020): 5557. doi.org/10.3390/molecules25235557. Jiang, H., X. Zhou, and L. Chen. "Asiaticoside Delays Senescence and Attenuate Generation of ROS in UV-Exposure Cells Through Regulates TGF-β1/Smad Pathway." Experimental and Therapeutic Medicine 24, no. 5 (November 2022). doi.org/10.3892/etm.2022.11603. Jung, E. et al. "Madecassoside Inhibits Melanin Synthesis by Blocking Ultraviolet-Induced Inflammation." Molecules 18, no. 12 (2013): 15724–36. doi.org/10.3390/molecules181215724. Sawant, O., and T. Kahn. "Management of Periorbital Hyperpigmentation: An Overview of Nature-Based Agents and Alternative Approaches." Dermatologic Therapy 33, no. 4 (July 2020): e13717. doi.org/10.1111/dth.13717. Sun, B. et al. "Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review." Frontiers in Pharmacology 11 (September 2020). doi.org/10.3389/fphar.2020.568032. Witkowska, K. et al. "Topical Application of Centella asiatica in Wound Healing: Recent Insights into Mechanisms and Clinical Efficacy." Pharmaceutics 16, no. 10 (September 2024): 1252. doi.org/10.3390/pharmaceutics16101252. GETTY IMAGES